Cold shock domain-containing protein E1

Cold shock domain-containing protein E1 (CSDE1) is an RNA-binding protein that regulates mRNA stability and translation through its involvement in translationally coupled mRNA turnover and cytoplasmic deadenylation (UniProt: O75534). The protein participates in decay pathways mediated by coding-region determinants of instability and is required for efficient stress granule formation, cellular structures that sequester mRNAs during stress conditions.

CSDE1 is broadly expressed and functions in post-transcriptional gene regulation across tissues (UniProt: O75534). The protein has also been implicated in viral translation, notably in human rhinovirus infection, suggesting roles in cellular defense mechanisms.

In Alzheimer's disease, CSDE1 is significantly down-regulated in post-mortem AD brain tissue compared to age-matched controls, with a mean log2 fold-change of −0.51 (Chaparral AD proteomics). This down-regulation was observed in a TMT-labeled proteomics study across subcellular fractions of human brain tissue, suggesting potential impairment of mRNA stability and translational control mechanisms in the AD brain environment.