Talin-2

Talin-2 (TLN2) is a large cytoplasmic protein that functions as a major component of focal adhesion plaques, where it links integrin receptors to the actin cytoskeleton and facilitates cell adhesion. The protein recruits PIP5K1C to focal adhesion sites and activates its kinase activity (UniProt: Q9Y4G6).

Talin-2 is expressed broadly across tissues and participates in cell–matrix interaction pathways critical for cellular adhesion and migration. No disease associations are documented in the UniProt record.

In Alzheimer's disease, Talin-2 is consistently downregulated in post-mortem AD brain tissue compared to age-matched controls, with a mean log2 fold-change of −0.73 across subcellular fractions (Chaparral AD proteomics). This reduction may reflect disruption of focal adhesion dynamics and cytoskeletal organization in AD pathology.