Amyloid beta A4 precursor protein-binding family B member 1-interacting protein

APBB1IP (Amyloid beta A4 precursor protein-binding family B member 1-interacting protein) is a 666-amino-acid cytoplasmic signaling protein that mediates Ras-to-actin cytoskeletal remodeling and Rap1-induced cell adhesion. It also suppresses insulin-induced promoter activities through AP1 and SRE regulatory elements (UniProt: Q7Z5R6).

The protein functions in signal transduction pathways governing cytoskeletal dynamics and cellular adhesion, with roles in integrating growth factor signaling. No baseline disease associations are annotated in UniProt curated records.

APBB1IP is elevated in Alzheimer's disease post-mortem brain tissue compared to age-matched controls (Chaparral AD proteomics). Quantitative TMT proteomics across four subcellular fractions (P2, P3, S2, S3) identified the protein as significantly upregulated with a mean log2 fold-change of 0.68, suggesting a potential involvement in AD-related neuronal remodeling or stress responses.