Talin-1

Talin-1 (TLN1) is a high molecular weight cytoskeletal protein concentrated at cell-matrix and cell-cell contact sites (UniProt: Q9Y490). It mediates connections between major cytoskeletal structures and the plasma membrane, and collaborates with KANK1 to organize cortical microtubule stabilizing complexes that regulate microtubule-actin crosstalk at focal adhesions.

Talin-1 is prominently involved in cytoskeletal organization and cellular adhesion dynamics across tissues. No specific disease associations are documented in UniProt for this protein.

Talin-1 is upregulated in Alzheimer's disease brain tissue. Chaparral AD proteomics data from human post-mortem AD brain versus age-matched controls (TMT-labeled DDA across four subcellular fractions) show a mean log2 fold-change of 1.10, indicating increased abundance in the AD condition. This elevation may reflect altered cytoskeletal remodeling or focal adhesion dynamics associated with AD pathology.