Isoform 2 of Non-selective voltage-gated ion channel VDAC3

Isoform 2 of VDAC3 (voltage-dependent anion channel 3) is a non-selective ion channel protein of 284 amino acids involved in regulating ion transport across membranes (UniProt: Q9Y277-2). VDAC3 localizes to the outer mitochondrial membrane and plays a role in metabolic regulation and apoptotic signaling, functioning as a key component of the mitochondrial permeability transition pore complex.

VDAC3 is expressed in human tissues and participates in mitochondrial bioenergetics and cellular stress responses. The UniProt record contains no explicitly curated disease associations for this isoform.

This protein shows decreased abundance in Alzheimer's Disease brain tissue. In a post-mortem AD proteomics study comparing human AD brain to age-matched controls via TMT-labeled DDA across four subcellular fractions (P2, P3, S2, S3), VDAC3 isoform 2 was down-regulated with a mean log2 fold-change of −0.852 (Chaparral AD proteomics). This reduction may reflect compromised mitochondrial function and altered energy metabolism in AD pathology.