Protein phosphatase 1 regulatory subunit 12C

Protein phosphatase 1 regulatory subunit 12C (PPP1R12C) is a regulatory protein that modulates myosin phosphatase activity (UniProt: Q9BZL4). This function positions it within cellular signaling pathways that regulate contractility and cytoskeletal dynamics. UniProt reports no established disease associations in its current annotation.

PPP1R12C shows Alzheimer's Disease relevance based on proteomic analysis of post-mortem AD brain tissue. In human brain samples compared to age-matched controls, this protein was downregulated (mean log2 fold-change: −0.23) across subcellular fractions in a TMT-labeled tandem mass spectrometry experiment examining four cellular compartments (Chaparral AD proteomics). The modest reduction in PPP1R12C levels in AD brain suggests potential alterations in myosin phosphatase-mediated signaling in the disease state, though the functional significance of this modest change remains to be determined.