MICOS complex subunit MIC60

IMMT encodes the MICOS complex subunit MIC60, a core component of the mitochondrial inner membrane protein complex. This protein maintains crista junction architecture and stabilizes contact sites between inner and outer mitochondrial membranes, playing essential roles in mitochondrial morphology and structural integrity (UniProt: Q16891).

The MICOS complex functions broadly across tissues in cellular respiration and energy metabolism. IMMT dysfunction has been implicated in mitochondrial structural disorders, though no specific Mendelian disease associations are documented in UniProt for this protein.

In Alzheimer's Disease, IMMT is significantly upregulated in post-mortem AD brain tissue compared to age-matched controls, with a mean log2 fold-change of 1.80 in TMT-labeled proteomic analysis of subcellular fractions (Chaparral AD proteomics). This upregulation suggests altered mitochondrial remodeling or attempted compensation in AD pathophysiology, though the functional consequence of increased MIC60 levels in neurodegeneration remains to be clarified.