Hematopoietic lineage cell-specific protein

Hematopoietic lineage cell-specific protein (HCLS1) is a 486-amino acid adaptor protein that functions as a substrate of antigen receptor-coupled tyrosine kinase and plays a role in antigen receptor signaling for clonal expansion and deletion in lymphoid cells (UniProt: P14317). The protein may also regulate gene expression in immune cells.

HCLS1 is primarily characterized in immune and hematopoietic contexts. No disease associations are documented in the UniProt record for this protein (UniProt: P14317).

In Alzheimer's Disease, HCLS1 shows a consistent up-regulation signature in human post-mortem AD brain tissue compared to age-matched controls, with a mean log2 fold-change of 1.18 (Chaparral AD proteomics). This elevation was detected via TMT-labeled quantitative proteomics across 4 subcellular fractions, suggesting a potential role in AD-associated neuroinflammatory or immune activation pathways.