Endophilin-A2

Endophilin-A2 (SH3GL1) is a membrane-associated protein with a molecular mass of ~41.5 kDa that functions in endocytosis by recruiting proteins to membranes exhibiting high curvature (UniProt: Q99961). The protein operates within cellular trafficking and endosomal pathways, playing a role in the internalization and sorting of membrane components.

In Alzheimer's Disease, endophilin-A2 shows reduced abundance in post-mortem AD brain tissue compared to age-matched controls. Quantitative proteomics analysis using TMT labeling across four subcellular fractions (P2, P3, S2, S3) in human post-mortem brain tissue detected a mean log2 fold-change of −0.53 (Chaparral AD proteomics), indicating modest downregulation. This reduction in an endocytosis-associated protein may reflect altered membrane trafficking and synaptic function characteristic of AD pathology, though the biological significance of this specific change requires further investigation.