Endophilin-A3

Endophilin-A3 (SH3GL3) is a 347-amino acid protein implicated in endocytosis and membrane organization. It is thought to recruit other proteins to highly curved membrane domains, facilitating vesicle formation and trafficking (UniProt: Q99963).

The protein is expressed in neuronal tissues where endocytic processes are particularly active. UniProt reports no established disease associations in its curated database.

In Alzheimer's disease, endophilin-A3 shows an ambiguous direction of change across subcellular fractions. Analysis of post-mortem AD brain tissue versus age-matched controls using TMT-labeled proteomics across four subcellular fractions (P2, P3, S2, S3) revealed a mean log2 fold-change of −0.071, indicating minimal overall change with divergent regulation across compartments (Chaparral AD proteomics). This compartment-specific pattern suggests potential redistribution rather than global dysregulation in AD pathology.