Ribosomal protein eL42-like

RPL36AL encodes a ribosomal protein in the eL42-like family, a component of the large ribosomal subunit involved in protein synthesis (UniProt: Q969Q0). This 106 amino acid protein is expressed in human tissues where ribosomal function is required.

The protein has no annotated disease associations in UniProt. However, RPL36AL shows relevance to Alzheimer's Disease pathology based on proteomics analysis.

In Alzheimer's Disease, RPL36AL is consistently down-regulated in post-mortem AD brain tissue compared to age-matched controls, with a mean log2 fold-change of −0.46 across examined subcellular fractions (Chaparral AD proteomics). This reduction in a core translational component may reflect broader disruption of protein synthesis capacity in AD pathology.