26S proteasome regulatory subunit 10B

PSMC6 (26S proteasome regulatory subunit 10B) is an AAA-ATPase component of the 26S proteasome complex that catalyzes ATP-dependent degradation of ubiquitinated proteins (UniProt: P62333). It is part of the heterohexameric ring that unfolds target proteins for translocation into the proteolytic chamber, thereby regulating protein homeostasis, cell cycle progression, apoptosis, and DNA damage repair.

The protein functions broadly in cellular protein quality control across multiple tissues and pathways dependent on proteasomal degradation. No baseline disease associations are listed in UniProt for PSMC6.

PSMC6 is downregulated in Alzheimer's disease brain tissue. Chaparral AD proteomics analysis of human post-mortem AD brain versus age-matched controls using TMT-labeled tandem mass spectrometry across four subcellular fractions detected a mean log2 fold-change of −0.29, indicating modest but consistent reduction. This decrease in proteasomal capacity may reflect impaired protein quality control mechanisms in AD, potentially contributing to accumulation of misfolded proteins characteristic of the disease.