Proteasome subunit alpha type-7

PSMA7 encodes proteasome subunit alpha type-7, a core component of the 20S proteasome complex that mediates ATP-dependent degradation of ubiquitinated proteins when associated with 19S regulatory particles to form the 26S proteasome (UniProt: O14818). The protein also participates in ubiquitin-independent proteolysis when bound to PA200 or PA28, and regulates diverse cellular processes including HIF-1A stability, androgen receptor signaling, and innate immune responses through MAVS modulation.

PSMA7 is broadly expressed and functions in protein homeostasis by removing misfolded, damaged, or functionally obsolete proteins across multiple cellular contexts (UniProt: O14818). No primary disease associations are documented in UniProt curated data.

PSMA7 is tagged for Alzheimer's Disease relevance in this dataset. Quantitative proteomics analysis of post-mortem AD brain tissue across four subcellular fractions showed ambiguous directional change, with a mean log2 fold-change of −0.0496 relative to age-matched controls, indicating minimal net difference in PSMA7 abundance (Chaparral AD proteomics). The modest effect size and inconsistent direction across fractions suggest PSMA7 expression is not substantially dysregulated in AD pathology.