Phosphoglycerate mutase 1

Phosphoglycerate mutase 1 (PGAM1) is a glycolytic enzyme that catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate through the action of 2,3-bisphosphoglycerate as a cofactor (UniProt: P18669). This reversible reaction is a critical step in the glycolytic pathway. The protein is 254 amino acids long with a molecular weight of approximately 28.8 kDa.

PGAM1 functions in cellular energy metabolism and has no formally documented disease associations in the UniProt knowledgebase (UniProt: P18669). However, glycolytic dysregulation has been implicated in neurodegenerative processes, and PGAM1 expression may respond to metabolic stress in brain tissue.

In Alzheimer's Disease, PGAM1 shows ambiguous regulation across subcellular fractions based on post-mortem human brain proteomics (Chaparral AD proteomics). Analysis of four subcellular fractions (P2, P3, S2, S3) using TMT-labeled quantitative mass spectrometry detected the protein in two fractions with a mean log2 fold-change of 0.15 relative to age-matched controls, indicating minimal and inconsistent directional change across cellular compartments.