Fructose-bisphosphate aldolase C

Fructose-bisphosphate aldolase C (ALDOC) is a glycolytic enzyme that catalyzes the reversible conversion of fructose 1,6-bisphosphate into two triose phosphates, playing a central role in both glycolysis and gluconeogenesis (UniProt: P09972). The protein is expressed across multiple tissues and is particularly notable in the brain, where it supports energy metabolism.

ALDOC is relevant to Alzheimer's disease, as reduced protein levels in AD brain tissue suggest impaired glycolytic capacity in neurodegeneration. In a comparison of post-mortem AD brain versus age-matched controls using quantitative proteomics (Chaparral AD proteomics), ALDOC was found to be significantly down-regulated with a mean log2 fold-change of −0.40 across one subcellular fraction. This decrease is consistent with metabolic dysfunction observed in AD pathology, where neurons show compromised energy production and altered glucose utilization.