protein
Fructose-bisphosphate aldolase C
Gene
ALDOC
Organism
Homo sapiens(9606)
Length
364 aa
Mass
39,456 Da
Fructose-bisphosphate aldolase C (ALDOC) is a glycolytic enzyme that catalyzes the reversible conversion of fructose 1,6-bisphosphate into two triose phosphates, playing a central role in both glycolysis and gluconeogenesis (UniProt: P09972). The protein is expressed across multiple tissues and is particularly notable in the brain, where it supports energy metabolism.
ALDOC is relevant to Alzheimer's disease, as reduced protein levels in AD brain tissue suggest impaired glycolytic capacity in neurodegeneration. In a comparison of post-mortem AD brain versus age-matched controls using quantitative proteomics (Chaparral AD proteomics), ALDOC was found to be significantly down-regulated with a mean log2 fold-change of −0.40 across one subcellular fraction. This decrease is consistent with metabolic dysfunction observed in AD pathology, where neurons show compromised energy production and altered glucose utilization.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↓ Down in ADP3
not detected
P2
-0.398
S2
not detected
S3
not detected
Mean log₂FC across detected fractions: -0.3978 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
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Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis
Sources
Last updated 5/8/2026, 6:33:59 AM