Phosphoglycerate mutase 2

Phosphoglycerate mutase 2 (PGAM2) is a glycolytic enzyme that catalyzes the interconversion of 3- and 2-phosphoglycerate, with 2,3-bisphosphoglycerate serving as the reaction primer (UniProt: P15259). The protein plays a central role in energy metabolism and glucose utilization pathways.

PGAM2 is expressed in skeletal muscle and other tissues involved in glycolytic metabolism. Mutations in PGAM2 cause glycogen storage disease 10 (GSD10), a metabolic disorder characterized by myoglobinuria, elevated serum creatine kinase, reduced phosphoglycerate mutase activity, and exercise intolerance (UniProt: P15259).

In Alzheimer's disease, PGAM2 is significantly upregulated in post-mortem AD brain tissue compared to age-matched controls (Chaparral AD proteomics). The mean log2 fold-change is 0.88 across 2 of 4 subcellular fractions analyzed by TMT-labeled tandem mass spectrometry. This upregulation suggests altered glycolytic flux or energy metabolism in AD pathology.