Laminin subunit gamma-1

Laminin subunit gamma-1 (LAMC1) is a structural protein of the extracellular matrix that mediates cell attachment, migration, and tissue organization through interactions with cell-surface receptors and other matrix components (UniProt: P11047). It functions as a component of laminin-1 and participates in agrin-induced receptor clustering via a MuSK-independent signaling pathway. The protein is 1609 amino acids in length and is expressed across human tissues.

LAMC1 is involved in extracellular matrix assembly and cell–matrix adhesion, processes relevant to neural development and tissue maintenance. UniProt records no primary disease associations for this protein, though its role in structural organization may be relevant to neurobiological contexts.

In Alzheimer's disease, LAMC1 shows evidence of upregulation in post-mortem AD brain tissue relative to age-matched controls, with a mean log2 fold-change of 0.48 (Chaparral AD proteomics). This modest increase was detected via mass spectrometry analysis of human brain fractions, suggesting potential alterations in extracellular matrix composition or dynamics in the AD brain environment.