GRB10-interacting GYF protein 1

GIGYF1 (GRB10-interacting GYF protein 1) is a 1,035-amino acid protein encoded by the GIGYF1 gene in humans (UniProt: O75420). The protein functions in the regulation of tyrosine kinase receptor signaling, potentially acting cooperatively with GRB10 to modulate receptor-mediated signaling cascades. It may enhance IGF1 receptor phosphorylation in response to IGF1 stimulation and facilitate phosphorylation of downstream signaling molecules including IRS1 and SHC1.

GIGYF1 is involved in growth factor signaling pathways, particularly those mediated by insulin-like growth factor 1 (IGF1) and related receptor tyrosine kinases. These pathways are critical for cell proliferation, differentiation, and metabolism. The protein's interaction with GRB10 suggests a role in fine-tuning growth-related signal transduction.

GIGYF1 is classified as SFARI Category 1 (SFARI Cat 1), indicating it is a high-confidence autism spectrum disorder (ASD) risk gene supported by strong genetic evidence. This classification suggests the protein may play an important role in neurodevelopmental processes relevant to autism pathogenesis, though the specific molecular mechanisms linking GIGYF1 dysfunction to ASD phenotypes require further investigation.