Trans-Golgi network integral membrane protein 2

Trans-Golgi network integral membrane protein 2 (TGOLN2) is a 437-amino-acid membrane protein encoded by the TGOLN2 gene. It is predicted to play a role in regulating membrane traffic to and from the trans-Golgi network, a key sorting and trafficking hub in the secretory pathway (UniProt: O43493).

TGOLN2 localizes to the trans-Golgi network, where it likely participates in vesicular transport and cargo sorting processes essential for protein secretion and intercellular communication. No primary disease associations are annotated in UniProt for this protein.

TGOLN2 is upregulated in Alzheimer's disease brain tissue. Quantitative proteomics in post-mortem AD brain compared to age-matched controls revealed a mean log2 fold-change of +0.688 (Chaparral AD proteomics). This elevation was detected across subcellular fractions in a TMT-labeled, data-dependent acquisition mass spectrometry study, suggesting that increased TGOLN2 protein levels may be part of the proteome remodeling associated with AD pathology, though the functional significance remains to be determined.