Golgin subfamily A member 4

GOLGA4 (Golgin subfamily A member 4) is a large coiled-coil protein involved in vesicular trafficking at the Golgi apparatus (UniProt: Q13439). It mediates delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through interaction with MACF1 and participates in endosome-to-Golgi trafficking. The protein is localized to the Golgi compartment where it functions in intracellular protein transport and membrane trafficking pathways.

GOLGA4 shows no disease associations listed in the UniProt record, though it operates in cellular pathways relevant to protein homeostasis and membrane dynamics. The protein is expressed in multiple tissues and its trafficking functions are critical for proper cellular organization and function.

In Alzheimer's disease, GOLGA4 is significantly upregulated in post-mortem AD brain tissue compared to age-matched controls (Chaparral AD proteomics). Quantitative TMT proteomics analysis detected the protein across multiple subcellular fractions with a mean log2 fold-change of +0.25, indicating modest but consistent elevation. This upregulation may reflect compensatory changes in vesicular trafficking or golgi remodeling occurring in the AD brain environment.