protein
Eukaryotic translation initiation factor 3 subunit F
aka eIF3f
Gene
EIF3F
Organism
Homo sapiens(9606)
Length
357 aa
Mass
37,564 Da
## Summary
EIF3F encodes eukaryotic translation initiation factor 3 subunit F (eIF3f), a component of the eIF-3 complex required for multiple steps in protein synthesis initiation (UniProt: O00303). The protein associates with the 40S ribosome to facilitate recruitment of initiation factors and formation of the 43S pre-initiation complex, while also promoting mRNA scanning and ribosomal recycling. Additionally, EIF3F deubiquitinates activated NOTCH1 to promote Notch signaling.
EIF3F functions in the translation initiation pathway with selective roles in translating mRNAs involved in cell proliferation, cycling, differentiation, and apoptosis. The protein is associated with intellectual developmental disorder, autosomal recessive 67 (MRT67), characterized by significantly below average intellectual functioning with impairments in adaptive behavior. Some MRT67 patients present with seizures and sensorineural hearing loss.
EIF3F is classified as SFARI Category 2 (UniProt: O00303; SFARI Cat 2), indicating a high-confidence genetic association with autism spectrum disorder based on available evidence in this dataset.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↑ Up in ADP3
+0.525
P2
not detected
S2
not detected
S3
not detected
Mean log₂FC across detected fractions: +0.5251 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Genetic Evidence · ASD
Strong candidate — functional studies support ASD association
Source: SFARI Gene database · gene.sfari.org
This protein is implicated in both ASD and Alzheimer's Disease. View all cross-disease proteins →
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772Inherited and De Novo Genetic Risk for Autism Impacts Shared Networks.
Ruzzo Elizabeth K et al.Cell2019PMID 31398340Inherited and multiple de novo mutations in autism/developmental delay risk genes suggest a multifactorial model.
Guo Hui et al.Molecular autism2018PMID 30564305Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.
C Yuen Ryan K et al.Nature neuroscience2017PMID 28263302Identification of common genetic risk variants for autism spectrum disorder.
Grove Jakob et al.Nature genetics2019PMID 30804558Synaptic, transcriptional and chromatin genes disrupted in autism.
De Rubeis Silvia et al.Nature2014PMID 25363760
Function
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773)
Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling
Disease associations
Intellectual developmental disorder, autosomal recessive 67MRT67
A form of intellectual disability, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Some MRT67 patients manifest seizures and sensorineural hearing loss.
Sources
Last updated 5/8/2026, 1:05:47 AM