protein
Adenylate kinase isoenzyme 5
aka AK 5
Gene
AK5
Organism
Homo sapiens(9606)
Length
562 aa
Mass
63,333 Da
Adenylate kinase isoenzyme 5 (AK5) is a nucleoside monophosphate kinase that catalyzes reversible phosphate transfer between nucleoside triphosphates and monophosphates, with activity on AMP, dAMP, and broader nucleoside diphosphate kinase capacity (UniProt: Q9Y6K8). The protein functions in cellular energy metabolism and nucleotide homeostasis across multiple tissues.
AK5 has been identified in Alzheimer's Disease proteomics studies but shows no specific disease annotation in UniProt. Analysis of post-mortem AD brain tissue versus age-matched controls using TMT-labeled quantitative proteomics across four subcellular fractions (P2, P3, S2, S3) revealed an ambiguous regulation pattern, with a mean log2 fold-change of 0.69 (Chaparral AD proteomics). The ambiguous direction suggests differential regulation across subcellular compartments or inconsistent changes between biological replicates, warranting further investigation to clarify AK5's role in AD pathology.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
⚠ Ambiguous — detected in AD samples, direction unclear across fractionsP3
-0.653
P2
not detected
S2
+2.026
S3
not detected
Mean log₂FC across detected fractions: +0.6866 (2 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
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Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity
Sources
Last updated 5/8/2026, 6:35:14 AM