protein
AP-3 complex subunit mu-1
Gene
AP3M1
Organism
Homo sapiens(9606)
Length
418 aa
Mass
46,939 Da
AP-3 complex subunit mu-1 (AP3M1) is a component of the AP-3 adaptor complex, which mediates vesicle budding from the Golgi membrane and trafficking to lysosomes (UniProt: Q9Y2T2). In neurons, the AP-3 complex works with BLOC-1 to direct cargo into vesicles at cell bodies for delivery to neurites and nerve terminals, linking it to synaptic function and neuronal trafficking pathways.
AP3M1 is downregulated in Alzheimer's disease brain tissue relative to age-matched controls, with a mean log2 fold-change of −0.97 across subcellular fractions in post-mortem TMT proteomics (Chaparral AD proteomics). This reduction may impair vesicle trafficking and lysosomal delivery, processes increasingly recognized as disrupted in AD pathology. The direction tag indicates consistent downregulation in the analyzed brain fractions (down). No SFARI curation is available for this protein.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↓ Down in ADP3
not detected
P2
not detected
S2
-0.969
S3
not detected
Mean log₂FC across detected fractions: -0.9686 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals
Sources
Last updated 5/8/2026, 6:32:14 AM