protein
Phospholipid-transporting ATPase IA
Gene
ATP8A1
Organism
Homo sapiens(9606)
Length
1164 aa
Mass
131,369 Da
ATP8A1 (phospholipid-transporting ATPase IA) is a P4-ATPase flippase component that catalyzes ATP-dependent translocation of aminophospholipids, particularly phosphatidylserine, from the outer to inner leaflet of cellular membranes (UniProt: Q9Y2Q0). This activity maintains phospholipid asymmetry and is implicated in vesicle formation and lipid signaling. The protein functions as an aminophospholipid translocase in neuronal cells, acting within a flippase complex with TMEM30A and playing a role in cell migration via phosphatidylethanolamine translocation (UniProt: Q9Y2Q0).
ATP8A1 shows increased expression in Alzheimer's Disease brain tissue relative to age-matched controls (Chaparral AD proteomics). Quantitative proteomics analysis using TMT labeling across four subcellular fractions from post-mortem human brain demonstrated a mean log2 fold-change of +0.35 in AD cases (Chaparral AD proteomics). The upregulation suggests potential involvement in AD-associated changes to neuronal membrane organization or phospholipid homeostasis, though the functional consequence remains to be determined.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↑ Up in ADP3
+0.352
P2
not detected
S2
not detected
S3
not detected
Mean log₂FC across detected fractions: +0.3516 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
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Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:31416931). Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS) (PubMed:31416931). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the cell membrane (By similarity). Acts as aminophospholipid translocase at the cell membrane in neuronal cells (By similarity)
Sources
Last updated 5/8/2026, 6:26:29 AM