protein
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
Gene
ASAP1
Organism
Homo sapiens(9606)
Length
1129 aa
Mass
125,498 Da
ASAP1 (Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1) is a phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein that regulates ARF (ADP ribosylation factor) proteins, particularly ARF1, ARF5, and ARF6 (UniProt: Q9ULH1). The protein coordinates membrane trafficking and actin cytoskeleton remodeling through interactions with SRC and PIP2, and participates in ciliogenesis as part of a ciliary targeting complex containing Rab11, Rabin8, and ARF4.
ASAP1 is involved in cellular differentiation processes and vesicular trafficking pathways critical for proper intracellular transport and organellar function. While no primary disease associations are documented in UniProt, the protein's role in membrane dynamics and cytoskeletal regulation implicates it in processes relevant to neuronal homeostasis.
In Alzheimer's disease, ASAP1 is significantly downregulated in human post-mortem AD brain compared to age-matched controls (Chaparral AD proteomics), with a mean log2 fold-change of −1.191 across subcellular fractions in TMT-labeled quantitative proteomics. This reduction may reflect compromised membrane trafficking or cytoskeletal dysfunction associated with AD pathology.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↓ Down in ADP3
not detected
P2
not detected
S2
-1.191
S3
not detected
Mean log₂FC across detected fractions: -1.191 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (PubMed:25673879)
Sources
Last updated 5/8/2026, 6:29:23 AM