Polypyrimidine tract-binding protein 2

Polypyrimidine tract-binding protein 2 (PTBP2) is an RNA-binding protein that recognizes intronic polypyrimidine tracts to mediate negative regulation of exon splicing and modulate translation (UniProt: Q9UKA9). The protein may antagonize NOVA1-dependent exon selection in a tissue-specific manner and has reduced affinity for RNA in certain contexts.

PTBP2 is broadly expressed across tissues with roles in pre-mRNA processing and translational control. The UniProt record reports no curated disease associations in its primary annotation (UniProt: Q9UKA9).

In Alzheimer's Disease, PTBP2 shows ambiguous regulation across subcellular fractions. Quantitative proteomics of post-mortem AD brain versus age-matched controls using TMT-labeled analysis across four subcellular fractions (P2, P3, S2, S3) yielded a mean log2 fold-change of −0.21, indicating minimal overall change; however, the direction designation reflects inconsistent regulation across individual fractions (Chaparral AD proteomics). This subtle, compartment-dependent pattern suggests PTBP2 involvement in AD pathology may be context-specific rather than uniformly altered.