Far upstream element-binding protein 2

Far upstream element-binding protein 2 (KHSRP) is an RNA-binding protein involved in mRNA metabolism and gene regulation (UniProt: Q92945). It binds dendritic targeting elements and participates in mRNA trafficking, alternative splicing regulation, and the degradation of AU-rich element-containing transcripts. The protein is also implicated in transcriptional control through interaction with far-upstream elements and downstream control sequences.

KHSRP functions broadly in post-transcriptional gene regulation across neuronal and other cell types. UniProt lists no curated disease associations for this protein, though its roles in mRNA stability and splicing suggest relevance to neurodegenerative processes (UniProt: Q92945).

In Alzheimer's disease, KHSRP shows decreased abundance in post-mortem AD brain tissue compared to age-matched controls, with a mean log2 fold-change of −0.34 across subcellular fractions (Chaparral AD proteomics). This downregulation may reflect altered mRNA processing capacity in AD pathology, though the modest magnitude of change warrants further mechanistic investigation.