protein
Anaphase-promoting complex subunit 7
aka APC7
Gene
ANAPC7
Organism
Homo sapiens(9606)
Length
565 aa
Mass
63,133 Da
ANAPC7 (Anaphase-promoting complex subunit 7) is a component of the APC/C, a cell cycle-regulated E3 ubiquitin ligase that mediates ubiquitination and degradation of cell cycle regulators (UniProt: Q9UJX3). The protein functions as an enzyme-substrate adapter that promotes the processive ubiquitination of specific targets, particularly mediating clearance of MKI67 during neuronal development. APC7 is involved in brain development through regulation of neuronal progenitor cell cycle exit.
Mutations in ANAPC7 cause Ferguson-Bonni neurodevelopmental syndrome (FERBON, MIM 619699), an autosomal recessive disorder characterized by global developmental delay, intellectual disability, and hypotonia with motor impairment (UniProt: Q9UJX3). The disease may also present with dysmorphic features, skeletal abnormalities, and hearing loss.
In Alzheimer's disease, ANAPC7 is significantly downregulated in post-mortem AD brain tissue compared to age-matched controls (Chaparral AD proteomics). Analysis of human AD brain using quantitative proteomics across subcellular fractions revealed a mean log2 fold-change of −0.33, indicating reduced expression of this cell cycle regulatory protein in AD pathology.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↓ Down in ADP3
-0.333
P2
not detected
S2
not detected
S3
not detected
Mean log₂FC across detected fractions: -0.3328 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). APC7 is not required for the assembly of the APC/C complex, but has an enzyme-substrate adapter activity mediating the processive ubiquitination of specific substrates (PubMed:34942119). Involved in brain development through the specific ubiquitination and clearance of MKI67 from constitutive heterochromatin after neuronal progenitors exit mitosis (PubMed:34942119)
Disease associations
Ferguson-Bonni neurodevelopmental syndromeFERBON
An autosomal recessive disorder characterized by global developmental delay, impaired intellectual development, and hypotonia with early motor delay. Additional features may include dysmorphic facies, mild skeletal abnormalities, and hearing loss.
Sources
Last updated 5/8/2026, 6:33:51 AM