protein
B-cell receptor-associated protein 29
aka BCR-associated protein 29, Bap29
Gene
BCAP29
Organism
Homo sapiens(9606)
Length
241 aa
Mass
28,320 Da
BCAP29 (B-cell receptor-associated protein 29) is a 241-amino acid protein that may facilitate anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi apparatus and may participate in CASP8-mediated apoptosis (UniProt: Q9UHQ4). The protein's specific tissue distribution and broader pathway roles remain incompletely characterized in the existing literature.
BCAP29 has been identified as upregulated in Alzheimer's Disease brain tissue. Analysis of human post-mortem AD brain tissue compared to age-matched controls using TMT-labeled tandem mass spectrometry across four subcellular fractions (P2, P3, S2, S3) revealed a mean log2 fold-change of +0.66 (Chaparral AD proteomics). The upregulation was detected in a single fraction during the study. This elevation may reflect altered membrane trafficking or apoptotic dysregulation associated with AD pathology, though the functional significance of this change remains to be determined.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↑ Up in ADP3
not detected
P2
not detected
S2
+0.664
S3
not detected
Mean log₂FC across detected fractions: +0.6645 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis (By similarity)
Sources
Last updated 5/8/2026, 6:25:14 AM