ATP-binding cassette sub-family F member 2

ABCF2 (ATP-binding cassette sub-family F member 2) is an ABC transporter protein belonging to the F subfamily, which comprises nucleotide-binding proteins involved in diverse cellular processes (UniProt: Q9UG63). Members of this family typically function in translational regulation and ribosomal biogenesis, though specific substrates and mechanisms for individual F-subfamily members remain incompletely characterized. The protein is 623 amino acids in length with a molecular weight of approximately 71 kDa.

ABCF2 is broadly expressed across human tissues. No specific tissue-restricted localization or primary disease association is documented in UniProt curated records (UniProt: Q9UG63).

In the context of Alzheimer's disease, ABCF2 shows reduced abundance in post-mortem AD brain tissue compared to age-matched controls (Chaparral AD proteomics). Proteomics analysis across four subcellular fractions yielded a mean log2 fold-change of −0.23, indicating modest but consistent downregulation. The functional consequence of decreased ABCF2 in AD pathogenesis remains to be established and may warrant further investigation into ribosomal and translational dysregulation in neurodegeneration.