Isoform 1 of Gamma-adducin

Gamma-adducin (ADD3, isoform 1) is a 75.7 kDa cytoplasmic protein involved in actin filament organization and cell membrane dynamics (UniProt: Q9UEY8-2). The protein functions in regulating the barbed ends of actin filaments and plays roles in cell morphology and synaptic plasticity through interactions with the spectrin-actin cytoskeleton.

ADD3 is expressed broadly across tissues including the central nervous system, where it contributes to neuronal architecture and axonal integrity. No specific disease annotations are listed in the UniProt record; however, adducins have been implicated in various neurological contexts through their structural roles in cytoskeletal organization.

In Alzheimer's Disease, gamma-adducin is upregulated in post-mortem brain tissue from AD patients compared to age-matched controls (Chaparral AD proteomics). Across three subcellular fractions examined in human post-mortem AD brain using TMT-labeled quantitative proteomics, the mean log2 fold-change was +0.72, indicating modest but consistent elevation. This upregulation may reflect compensatory cytoskeletal remodeling or altered synaptic dynamics associated with neurodegeneration in AD.