protein
Ataxin-10
Gene
ATXN10
Organism
Homo sapiens(9606)
Length
475 aa
Mass
53,489 Da
Ataxin-10 (ATXN10) is a 475-amino-acid protein that regulates cytokinesis and may stimulate protein glycosylation (UniProt: Q9UBB4). It promotes neuritogenesis through Ras-MAP kinase pathway activation and is essential for cerebellar neuron survival, though it appears dispensable for ciliogenesis.
The protein is primarily implicated in spinocerebellar ataxia 10 (SCA10), an autosomal dominant cerebellar disorder characterized by progressive gait incoordination and neuronal degeneration in the cerebellum and brainstem (UniProt: Q9UBB4). Its role in cerebellar neuron survival suggests relevance to degenerative neurological phenotypes.
In Alzheimer's disease, ataxin-10 is upregulated in post-mortem AD brain tissue compared to age-matched controls, with a mean log2 fold-change of 0.45 in human TMT-labeled proteomics across subcellular fractions (Chaparral AD proteomics). This elevation may reflect compensatory neuritogenic signaling or altered protein glycosylation during AD pathogenesis.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↑ Up in ADP3
+0.452
P2
not detected
S2
not detected
S3
not detected
Mean log₂FC across detected fractions: +0.4521 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
May play a role in the regulation of cytokinesis (PubMed:21857149, PubMed:25666058). May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons (By similarity). Does not appear to play a major role in ciliogenesis (By similarity)
Disease associations
Spinocerebellar ataxia 10SCA10
Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA10 is an autosomal dominant cerebellar ataxia (ADCA).
Sources
Last updated 5/8/2026, 6:26:20 AM