Costars family protein ABRACL

ABRACL (Costars family protein ABRACL) is a small 81-amino acid protein encoded by the ABRACL gene in humans (UniProt: Q9P1F3). While specific molecular function annotations are not detailed in UniProt records, it is classified as a member of the Costars protein family, suggesting involvement in cellular processes related to this protein family.

Tissue distribution and broader disease associations for ABRACL are not curated in UniProt. The protein's specific physiological roles and tissue localization require further characterization through experimental studies.

ABRACL shows potential relevance to Alzheimer's Disease based on proteomics evidence (Chaparral AD proteomics). In post-mortem AD brain tissue compared to age-matched controls, ABRACL is upregulated with a mean log2 fold-change of 0.91, suggesting increased protein abundance in AD brain. This upregulation was detected in a comprehensive analysis of four subcellular fractions (P2, P3, S2, S3) using TMT-labeled tandem mass spectrometry, though the change was identified in a single fraction. The biological significance of this elevation in AD pathology remains to be established.