Septin-10

Septin-10 is a filament-forming cytoskeletal GTPase encoded by SEPTIN10 (UniProt: Q9P0V9). It is a 454-amino acid protein with a molecular mass of approximately 52.6 kDa that may participate in cytokinesis through its role in organizing and maintaining cellular cytoskeletal structures.

Septins are a conserved family of GTP-binding proteins involved in cell division, membrane dynamics, and cytoskeletal organization. Septin-10 localizes to various cellular compartments and is expressed across tissues; however, no UniProt-curated disease associations are currently documented for this protein.

In Alzheimer's disease, Septin-10 shows increased abundance in post-mortem AD brain tissue compared to age-matched controls (mean log2 fold-change +0.79; Chaparral AD proteomics). This upregulation was detected via quantitative proteomics of four subcellular fractions from human brain tissue, suggesting a potential role in AD-associated cytoskeletal or cytokinesis-related pathology, though the functional significance remains to be determined.