Septin-6

Septin-6 is a filament-forming cytoskeletal GTPase encoded by SEPTIN6 (UniProt: Q14141). It functions in organization of the actin cytoskeleton and is required for normal cytokinesis. The protein also forms filamentous structures with other septins at the sperm annulus, contributing to sperm tail structural integrity and motility during postmeiotic differentiation.

Septins are highly conserved GTP-binding proteins implicated in diverse cellular processes including membrane organization and cell division. The UniProt record notes no explicit disease associations in baseline curated entries, though septins have been implicated in neurodegenerative processes through their roles in cytoskeletal dynamics and cellular compartmentalization.

Septin-6 is upregulated in Alzheimer's disease brain tissue, with a mean log2 fold-change of 0.65 compared to age-matched controls (Chaparral AD proteomics). This elevation was detected in human post-mortem AD brain via TMT-labeled proteomics across subcellular fractions, suggesting potential involvement in AD-associated cytoskeletal or structural reorganization.