Actin-related protein 10

Actin-related protein 10 (ACTR10) is a 417 amino acid component of the dynactin complex that serves as a molecular motor activator, facilitating ultra-processive transport of cargo along microtubules via dynein (UniProt: Q9NZ32). The protein functions within the broader cellular machinery governing intracellular trafficking and cytoskeletal dynamics, essential processes across multiple cell types and tissues.

In the context of Alzheimer's Disease, ACTR10 shows reduced abundance in human post-mortem AD brain compared to age-matched controls (Chaparral AD proteomics). Analysis of TMT-labeled samples across four subcellular fractions revealed a mean log2 fold-change of −0.4271, indicating consistent downregulation. This reduction in dynactin-associated protein levels may reflect impaired axonal transport capacity, a feature increasingly recognized in AD pathophysiology. No UniProt-curated disease associations are documented for ACTR10.