protein
Actin-related protein 10
Gene
ACTR10
Organism
Homo sapiens(9606)
Length
417 aa
Mass
46,307 Da
Actin-related protein 10 (ACTR10) is a 417 amino acid component of the dynactin complex that serves as a molecular motor activator, facilitating ultra-processive transport of cargo along microtubules via dynein (UniProt: Q9NZ32). The protein functions within the broader cellular machinery governing intracellular trafficking and cytoskeletal dynamics, essential processes across multiple cell types and tissues.
In the context of Alzheimer's Disease, ACTR10 shows reduced abundance in human post-mortem AD brain compared to age-matched controls (Chaparral AD proteomics). Analysis of TMT-labeled samples across four subcellular fractions revealed a mean log2 fold-change of −0.4271, indicating consistent downregulation. This reduction in dynactin-associated protein levels may reflect impaired axonal transport capacity, a feature increasingly recognized in AD pathophysiology. No UniProt-curated disease associations are documented for ACTR10.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↓ Down in ADP3
not detected
P2
not detected
S2
-0.621
S3
-0.233
Mean log₂FC across detected fractions: -0.4271 (2 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules
Sources
Last updated 5/8/2026, 6:37:23 AM