ADP-ribosylation factor-like protein 15

ARL15 (ADP-ribosylation factor-like protein 15) is a small GTPase belonging to the ARF family of regulatory proteins (UniProt: Q9NXU5). Like other ARF-family members, it likely functions in vesicular trafficking and cellular signaling, though specific molecular interactions are not detailed in available UniProt annotations.

ARL15 is a 204-amino-acid protein with a molecular mass of approximately 22.9 kDa. UniProt records no annotated disease associations or established tissue-specific expression patterns for this protein.

In Alzheimer's disease, ARL15 is significantly downregulated in post-mortem human brain tissue compared to age-matched controls, with a mean log2 fold-change of −0.60 (Chaparral AD proteomics). This reduction was detected across subcellular fractions in a TMT-labeled, data-dependent acquisition proteomics study, suggesting potential involvement in AD-related pathology, though the mechanistic significance of this downregulation remains to be determined.