NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

NDUFB11 is an accessory subunit of mitochondrial Complex I (NADH dehydrogenase), a key respiratory chain enzyme that transfers electrons from NADH to ubiquinone. Although not directly involved in catalysis, it is essential for Complex I assembly and function (UniProt: Q9NX14). NDUFB11 is expressed in mitochondria across tissues and has been associated with mitochondrial dysfunction in several inherited conditions, including mitochondrial complex I deficiency and linear skin defects with multiple congenital anomalies.

In Alzheimer's disease, NDUFB11 abundance shows an ambiguous direction across subcellular fractions in post-mortem AD brain tissue compared to age-matched controls (Chaparral AD proteomics). The mean log2 fold-change is 0.1892 across two analyzed fractions from TMT-labeled quantitative proteomics, suggesting modest and inconsistent changes that may reflect compartment-specific alterations in mitochondrial respiratory capacity during AD pathology. This modest elevation warrants further investigation into whether Complex I dysfunction contributes to AD neurodegeneration.