NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

NDUFA7 encodes NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7, an accessory subunit of mitochondrial Complex I. Although not directly involved in catalysis, it supports the enzyme's function in transferring electrons from NADH to ubiquinone within the respiratory chain (UniProt: O95182).

Complex I is a core component of oxidative phosphorylation and energy metabolism in mitochondria-rich tissues, including the brain. No specific disease associations are annotated in UniProt for this protein.

NDUFA7 is upregulated in Alzheimer's Disease brain tissue relative to age-matched controls, with a mean log2 fold-change of 1.76 in post-mortem AD brain samples analyzed by quantitative proteomics (Chaparral AD proteomics). This elevation may reflect compensatory changes in mitochondrial function or metabolic stress response characteristic of AD pathology.