protein
Armadillo repeat-containing protein 1
Gene
ARMC1
Organism
Homo sapiens(9606)
Length
282 aa
Mass
31,281 Da
ARMC1 (armadillo repeat-containing protein 1) is a 282-amino-acid protein that functions in the regulation of mitochondrial dynamics (UniProt: Q9NVT9). It associates with the mitochondrial contact site and cristae organizing system (MICOS) complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex, playing a role in determining mitochondrial length, distribution, and motility.
ARMC1 is expressed in mitochondrial compartments and participates in organellar organization and dynamics pathways. No disease associations are annotated in the UniProt record.
In Alzheimer's disease, ARMC1 is significantly downregulated in post-mortem AD brain tissue relative to age-matched controls (Chaparral AD proteomics). The mean log2 fold-change is −0.6148 based on quantitative proteomics analysis of four subcellular fractions from TMT-labeled, data-dependent acquisition mass spectrometry. This downregulation may reflect impaired mitochondrial function or dynamics in the AD brain.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↓ Down in ADP3
not detected
P2
not detected
S2
-0.615
S3
not detected
Mean log₂FC across detected fractions: -0.6148 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility
Sources
Last updated 5/8/2026, 6:29:53 AM