DnaJ homolog subfamily C member 11

DNAJC11 is a DnaJ homolog subfamily C member that functions in mitochondrial inner membrane organization, primarily through association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex (UniProt: Q9NVH1). The protein localizes to mitochondria where it facilitates structural organization critical for mitochondrial function and biogenesis.

No baseline disease associations are documented in UniProt. However, DNAJC11 has been identified as relevant to Alzheimer's Disease pathology through proteomic analysis. In post-mortem AD brain tissue compared to age-matched controls, DNAJC11 is significantly downregulated (mean log2FC: −0.281) across the analyzed subcellular fractions, as measured by TMT-labeled quantitative proteomics (Chaparral AD proteomics). This downregulation suggests impaired mitochondrial organization capacity in AD brain, potentially contributing to the mitochondrial dysfunction observed in Alzheimer's pathogenesis.