protein
ATP-binding cassette sub-family F member 3
Gene
ABCF3
Organism
Homo sapiens(9606)
Length
709 aa
Mass
79,745 Da
ABCF3 (ATP-binding cassette sub-family F member 3) is an ABC transporter family member encoded by the ABCF3 gene in humans (UniProt: Q9NUQ8). The protein displays an antiviral effect against flaviviruses such as West Nile virus in the presence of OAS1B, suggesting a role in innate immune defense mechanisms.
ABCF3 is a 709 amino acid protein with a molecular mass of approximately 79.7 kDa. No specific tissue localization or canonical disease associations are documented in UniProt, though the antiviral function implicates potential relevance to neuroinflammatory pathways.
ABCF3 is down-regulated in Alzheimer's Disease brain tissue compared to age-matched controls (Chaparral AD proteomics). Analysis of post-mortem AD brain across four subcellular fractions using TMT-labeled quantitative proteomics showed a mean log2 fold-change of −0.3165, indicating modest reduction. This decreased expression may reflect altered innate immune responses or metabolic changes associated with AD pathology.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↓ Down in ADP3
-0.317
P2
not detected
S2
not detected
S3
not detected
Mean log₂FC across detected fractions: -0.3165 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B
Sources
Last updated 5/8/2026, 6:39:03 AM