RNA-binding protein 12

RNA-binding protein 12 (RBM12) is a 932-amino-acid RNA-binding protein encoded by the RBM12 gene in humans (UniProt: Q9NTZ6). The protein functions in post-transcriptional gene regulation through its capacity to bind and modulate RNA molecules, though specific molecular targets and regulatory mechanisms remain to be fully characterized.

RBM12 has been associated with schizophrenia (SCZD19, MIM 617629) according to UniProt records, suggesting a role in neuropsychiatric function. Beyond this curated association, the broader expression context and tissue-specific roles of this RNA-binding protein in normal physiology require further investigation.

In Alzheimer's Disease, RBM12 is significantly upregulated in post-mortem AD brain tissue relative to age-matched controls (Chaparral AD proteomics). Analysis of human post-mortem AD brain using TMT-labeled, data-dependent acquisition proteomics across four subcellular fractions (P2, P3, S2, S3) revealed a mean log₂ fold-change of 0.62, indicating consistent elevation. This upregulation may reflect compensatory or pathogenic responses to neurodegeneration, though the functional consequences remain to be determined.