protein
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma
Gene
AGPAT3
Organism
Homo sapiens(9606)
Length
376 aa
Mass
43,381 Da
AGPAT3 (1-acyl-sn-glycerol-3-phosphate acyltransferase gamma) is an acyltransferase that catalyzes the conversion of lysophosphatidic acid into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (UniProt: Q9NRZ7). The enzyme acts on a range of fatty acyl-CoA donors (C16:0–C20:4) with preference for arachidonoyl-CoA, and also processes other lysophospholipid substrates including lysophosphatidylcholine and lysophosphatidylinositol (UniProt: Q9NRZ7).
AGPAT3 participates in glycerophospholipid metabolism and is involved in the synthesis of complex membrane phospholipids. The enzyme is widely expressed across tissues (UniProt: Q9NRZ7). No primary disease associations are documented in UniProt curated data for this protein.
In Alzheimer's disease, AGPAT3 is downregulated in post-mortem brain tissue compared to age-matched controls (mean log2FC: −0.51), based on TMT-labeled proteomics analysis across multiple subcellular fractions (Chaparral AD proteomics). This reduction in AGPAT3 abundance may reflect altered phospholipid remodeling dynamics in AD brain, though the functional consequence of this downregulation remains to be determined.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↓ Down in ADP3
not detected
P2
not detected
S2
not detected
S3
-0.506
Mean log₂FC across detected fractions: -0.5064 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:21173190). Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor (PubMed:21173190). Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA (PubMed:21173190). Has a preference for arachidonoyl-CoA as a donor (By similarity). Also has a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lysophosphatidylinositol (LPI) into phosphatidylinositol (By similarity)
Sources
Last updated 5/8/2026, 6:36:03 AM