Lysophosphatidic acid phosphatase type 6

Lysophosphatidic acid phosphatase type 6 (ACP6) is a serine hydrolase that catalyzes the breakdown of lysophosphatidic acid (LPA) to monoacylglycerol, with greatest activity toward medium-chain fatty acid variants including myristate, oleate, and palmitate (UniProt: Q9NPH0). This enzymatic activity suggests a role in lipid metabolism and membrane remodeling, processes fundamental to neuronal function.

ACP6 is expressed in human tissues with involvement in phospholipid catabolism. No primary disease associations are currently documented in the UniProt record for this protein (UniProt: Q9NPH0).

In Alzheimer's Disease, ACP6 is significantly upregulated in post-mortem AD brain tissue compared to age-matched controls, with a mean log2 fold-change of 0.58 across subcellular fractions (Chaparral AD proteomics). This elevation was observed in TMT-labeled quantitative proteomics analysis across multiple subcellular compartments (P2, P3, S2, S3 fractions). The consistent upregulation suggests a potential compensatory or pathological increase in LPA catabolism associated with AD pathology, though the functional consequences remain to be elucidated.