Dynein light chain roadblock-type 1

Dynein light chain roadblock-type 1 (DYNLRB1) is a 96-amino-acid accessory component of the cytoplasmic dynein 1 motor complex (UniProt: Q9NP97). It functions as a structural and regulatory element linking dynein to cargo and adapter proteins, enabling retrograde transport of vesicles and organelles along microtubules and supporting ciliary integrity.

DYNLRB1 operates within the microtubule-based intracellular transport pathway, essential for neuronal function and vesicular trafficking. UniProt records no primary disease associations for this protein.

In Alzheimer's Disease, DYNLRB1 is consistently downregulated in post-mortem human brain tissue compared to age-matched controls (Chaparral AD proteomics: mean log2 fold-change −0.465 across multiple subcellular fractions). This downregulation may reflect compromised axonal transport and organellar trafficking in AD pathology, though the functional consequences require further investigation.