Dynein light chain 2, cytoplasmic

Dynein light chain 2, cytoplasmic (DYNLL2) is a small accessory protein that functions as a non-catalytic component of the cytoplasmic dynein 1 motor complex (UniProt: Q96FJ2). It plays a role in linking dynein to cargo and regulatory adapter proteins, facilitating retrograde transport of vesicles and organelles along microtubules and contributing to cytoskeletal organization.

DYNLL2 is a cytoplasmic protein involved in intracellular motor function and vesicular trafficking. No primary disease associations are documented in UniProt for this protein.

In Alzheimer's disease, DYNLL2 shows reduced abundance in human post-mortem AD brain compared to age-matched controls, with a mean log2 fold-change of −0.33 (Chaparral AD proteomics). This down-regulation was detected across subcellular fractions in TMT-labeled, data-dependent acquisition proteomics. The modest decrease may reflect impaired dynein-mediated transport capacity in AD pathology.