protein
Adipocyte plasma membrane-associated protein
Gene
APMAP
Organism
Homo sapiens(9606)
Length
416 aa
Mass
46,480 Da
APMAP (adipocyte plasma membrane-associated protein) is a 416-amino acid enzyme that exhibits strong arylesterase activity and may participate in adipocyte differentiation (UniProt: Q9HDC9). The protein's precise physiological role remains incompletely characterized, though its enzymatic properties suggest involvement in lipid metabolism or detoxification pathways.
APMAP is primarily associated with adipose tissue biology based on its naming and functional annotation. No disease associations are documented in UniProt for this protein.
In Alzheimer's disease, APMAP is upregulated in post-mortem human AD brain tissue compared to age-matched controls, with a mean log2 fold-change of +1.10 (Chaparral AD proteomics). The protein was detected in a subcellular fractionation study of AD brain using TMT-labeled quantitative proteomics. The functional significance of this upregulation in AD pathology is not yet established and warrants further investigation.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↑ Up in ADP3
not detected
P2
not detected
S2
+1.098
S3
not detected
Mean log₂FC across detected fractions: +1.0976 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation
Sources
Last updated 5/8/2026, 6:31:33 AM