Anoctamin-8

Anoctamin-8 (ANO8) is a chloride channel family member that, despite sequence homology to other anoctamins, does not exhibit calcium-activated chloride channel activity (UniProt: Q9HCE9). The protein is a 1232-amino acid transmembrane protein with a molecular mass of approximately 136 kDa. Its specific cellular and tissue localization patterns remain to be fully characterized.

ANO8 has not been documented in UniProt as carrying direct disease associations from clinical literature. However, recent proteomics work has identified its involvement in Alzheimer's Disease pathology. In post-mortem brain tissue from Alzheimer's patients compared to age-matched controls, ANO8 expression is significantly reduced, with a mean log2 fold-change of −0.33 across subcellular fractions (Chaparral AD proteomics). This downregulation was detected via quantitative mass spectrometry (TMT-labeled, DDA) across multiple cellular compartments (P2, P3, S2, S3 fractions), suggesting that loss of ANO8 protein may be relevant to AD-associated neuropathology. The functional consequence of this reduction requires further investigation.