RWD domain-containing protein 1

RWDD1 (RWD domain-containing protein 1) is a 243-amino acid protein that functions in protein homeostasis and transcriptional regulation (UniProt: Q9H446). It protects the protein DRG2 from proteolytic degradation and may act as a coactivator of the androgen receptor during development. The protein is broadly expressed across tissues and participates in cellular regulatory networks involving protein stability and nuclear hormone signaling.

RWDD1 shows no documented disease associations in the UniProt record. However, proteomics profiling in Alzheimer's disease brain tissue has revealed altered expression patterns. In post-mortem AD brain compared to age-matched controls, RWDD1 is upregulated with a mean log2 fold-change of 0.63 across one subcellular fraction (Chaparral AD proteomics), suggesting increased abundance in disease-affected tissue. This finding, derived from TMT-labeled tandem mass spectrometry across multiple subcellular fractions, indicates potential involvement in AD-related pathological processes, though the functional consequences of this elevation remain to be determined.